They are going to be as safe as you make them.
If you meet someone online and decide to meet them face to face then you need to make sure you protect yourself as much as possible. Do not plan to meet anywhere secluded, dark, or anywhere you don't know.
Meet up during the day in public, at least to ensure the person you are meeting is not a fucking psycho.
Let someone know where you are going and who you are meeting. Pass on the persons details to them.
Talk to the person on skype first. Time wasters and nutjobs don't tend to show their face before meets. Get to know them a little before you commit to meeting face to face.
While some people will want to be as discrete as possible there has to be a certain amount of trust given before the meet, it is not unreasonable for you to demand some openness, it is your neck that is on the line if shit turns sour.
Just look at that poor guy who was assaulted last week after meeting someone they talked to online. You can be sure they didnt put a common sense plan into action before that meet. It could have been the end of them. If they had made a bit more of an effort to do video chats before they met it might not have ended up the way it did.
Don't let your being horny get in the way of your safety. All it takes is one asshole with a problem with you and your sexual orientation to post a classified that will give them an opportunity to do you damage.
Stay sober, dont leave your drink unattended.
Dont deviate from the meeting plan at the last minute.
Stay somewhere public. If you go back to their house/hotel make sure you let them see you talking to someone on your phone to let them know where you are going, even if it is only an act.
Tell a friend where you are going to be and who you are meeting.
If something seems off, leave.